Biology 1001A Lecture Notes - Lecture 2: Thymidine, Retrovirus, Scandinavia
24 Dec 2015
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Beth"s office hours: mon-thurs 12:00-1:00, no email req. Evolutionary origin/history? (one origin or many? cellular organism lost independent metabolism transposons, selfish genetic elements of dna or rna gained the ability to enter and exit different cells (jumping genes) viruses are more ancient than cellular life. Dna replication dna transcription rna translation protein. Reverse transcription (no proof reading in reverse transcription disobeys fast replication and lots of mutation because no proofreading) How to attack virus/ minimize side affect is antiviral drugs, attack virus specific steps: virion enters cell reverse transcriptase integrase splices viral dna into host dna. Transcription, translation, protease (seeks to break the chains of immature virus) New virions assemble, bud or burst out. Azt the first anti-hiv drug: azt mimics thymidine and fools" rt, ordinary reverse transcriptase, azt molecule incorporates (added to dna being constructed, dna synthesis cannot continue.
