Biology 1001A Lecture Notes - Lecture 2: Antiviral Drug, Reverse Transcriptase, Dna Replication
26 Sep 2016
School
Department
Course
Professor
Document Summary
Lecture 2 notes: evolution in action: hiv cycle 1. But they do have their own genetic information, and they can evolve, they have evolutionary history. Distinguished by their shape, single strand/double strand genome. Occurs worldwide, but not all areas are equally affected. It is ground zero for hiv, it was transmitted to humans, jumped the species barrier from chimpanzees to humans, around 100yrs ago, happened in are of wild chimps, therefore africa. Antiviral drugs, have worse side effects than antibacterial, antifungals, bc the antivirals have to affect the host cell. Hiv disobeys the central dogma of molecular biology. Bad: mutation rate is really high compared to things that don"t have to go through the extra step experience a mutation that will help it replicate more quickly enables it to evolve quickly. Good: gives a target for drug design, targets reverse transcription, to create drugs with minimal side effects in theory. To minimize side effects of antiviral drug, attack virus-specific steps.
