Biology 1001A Lecture Notes - Lecture 8: Thymine, Comparative Genomics, Hydrogen Bond
19 Sep 2013
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Lecture outcomes different types of genomic variation among humans: venter individual genome sequence showed. 1. 2 million variants: of variant bases are snps (single nucleotide polymorphism) Are cnv, inversions etc (includes deletions and insertions: each person has about 1000 cnv affecting 35% of genes. Each person has about 300 variants in insertion of retro elements (eg. lines, sines) Long interspersed elements[9] are a group of genetic elements that are found in large numbers in eukaryotic genomes. Code for the enzyme reverse transcriptase, and many lines also code for an endonuclease. Short interspersed elements[9] are short dna sequences (<500 bases[17]) The most common sines in primates are calledalu sequences. Alu elements are approximately 350 base pairs long, do not contain any coding sequences, and can be recognized by the restriction enzyme alui (hence the name). With about 1,500,000 copies, sines make up about 11% of the human genome.
