Biology 1001A Lecture Notes - Lecture 5: Active Transport, Phenylalanine, Facilitated Diffusion
24 Apr 2016
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Bio 1002b lecture 5: the plasma membrane. Atp-binding cassette (abc) transporter: transmembrane protein that binds atp. Saturated: solid at rm temp, bad for you, linear, able to pack together to form plaque in o arteries, no double bonds. 1 in 22 canadians carry the recessive defective allele. Cholera: bacterial infection, kills by massive water loss (outbreaks common in europe 19th. If heterozygote cc, you would lose less water if you got cholera greater probability of survival. Cystic fibrosis transconductance regulator (cftr): transmembrane protein that, when o defective, causes cystic fibrosis (normally regulates amount of chloride ions that pass through membrane) Cilia with mucus normally lines epithelial cells in lungs, gets dirt out of lungs. In cystic fibrosis, mucus dries out bacteria thrive & patient is prone to bacterial infections. F508: most common mutation producing cystic fibrosis (70% of all cases) deletion of o phenylalanine at amino acid #508 o chaperone protein: detects stability of folded protein.
