Biology 1002B Lecture 24: BIO1002B, lec 24
Document Summary
Figuring out if genes are homologous is more sensible than guring out if physical traits are. Genes do not need to have the same function for them to be homologous. If you knock out glsa in chlamydomonas, chlamy is ne. If you knock out glsa in volvox, volvox is not ne. If you replace the glsa in volvox with chlamy"s glsa, volvox is ne. Sequence alignment uses proteins or genes or cdna to detect similarity. A huge area of computer science is between computer science and biology. Sequencing dna is cheap, putting meaning to it is computationally harder. There are two di erent approaches to aligning similarity . Attempts to align every single base to see which alignment gives the strongest match. If you have an unknown gene you want to search a database and you want to nd results very quickly - this is why the quickness of local is important. Repository of all genome, gene & protein data.
