Biology 1002B Lecture Notes - Lecture 23: Synonymous Substitution, Asymmetric Cell Division, Volvox
Document Summary
In volvox, it is required for asymmetric cell division. The glsa gene can be put into volvox and still work fine. To determine if two sequences are homologous. Differences between global versus local (advantages of each). Global alignment takes two genes and aligns them end to end. Local alignment does not force end to end alignment, looks for smaller regions of high similarity. Global alignment is convenient when you have two similar sequences (when you already know they are similar). But for unknown sequences, local alignment is more convenient: it is faster, reflects different proteins that share domains/ motifs. Concept of i (information) and why an amino acid sequence holds more information than a nucleotide sequence of the same length. Protein sequence holds more bits of information, has more statistical information. A nucleotide holds two bits of information a 00, g 01, c 10, t 11. Amino acid sequence is able to detect more similar sequences.
