Biology 1002B Lecture Notes - Lecture 24: Experimental Evolution, Chlamydomonas, Red

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Most studies of evolution are constrained by two facts: most organisms evolve slowly, can"t go back in time to examine ancestral forms. Model systems for experimental evolution include viruses, bacteria, chlamydomonas, drosophila, and yeast. They are the most commonly used because they have a short generation time (minutes to hours). To nail down the genetic basis of the adaptation, you would sequence the two strains and then compare them with alignment ( nd non-synonymous substitutions). Friday, april 1, 2016: number of mutations over 30 000 generations??? (billions!!, every base in the genome has been changed in those cells. Billions of mutations in a 4. 6 bp genome. In generations previous to the a-3, you get populations with higher culture density, then even higher, until you each a plateau. The a-3 line plateau of populations acquired a cit+ gene, so they do have the ability to consume citrate as a carbon source.

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