Biology 1201A Lecture Notes - Lecture 3: Dna Mismatch Repair, Dna Replication, Telomerase
Document Summary
Read 3" to 5" lay down nucleoides 5" to 3". Rna primers provide the 3" hydroxyl group at regular intervals through the strand. When primer is removed in the middle the gaps will be illed with dna but when its at the end there is no 3" hydroxyl group so the chromosome become shorter and shorter. What helps deal with this problem is the enzyme telomerase. Aging is linked to the shortening of your chromosome more speciically shortening of the telomeres. Telomerase adds extra dna to the end of the chromosome. Will add nucleoides to the parent strand and adds a rna template extending the chromosome then dna replicaion can do what it does. Telomerase acts like dna polymerase, it complementary base pairs against the rna. The primer at the end will sill be removed but since it the telomeres got added its not important info that is being lost its just the added garbage .