Biology 1201A Lecture Notes - Lecture 3: Cri Du Chat, Depurination, Transposase
20 Mar 2016
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2016-03-20 (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Mutations: double stranded, heritable changes in dna sequences. Transposition: how it moves from place to place within genome of given cell: cut and paste sections of dna, copy and paste sections of dna. Starts with contact b/w te and the target site. Cannot exist free from dna its integrated in. Type of recombination that doesn"t require homology. Transposase enzyme recognizes inverted sequences (on both ends of me) and then catalyzes transposition. Opinion at time of me discovery was nah genes have fixed locations. Retrotransposons: transposition occurs via rna intermediate copy of te, retroviruses may have evolved from retrotransposons. Tautomeric shifts: spontaneous shift b/w isomers of bases, results in alternative h bond patterns. Deamination: removal of amine group from base, results in alternative h bond patterns. Depurination: disruption of bond between purine and deoxyribose, one base (ex.
