Biology 1202B Lecture Notes - Embryonic Stem Cell, Adult Stem Cell, Sox2
24 Apr 2013
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Stem cells (useful for cancers, blood disorders, immune disorders, metabolic disorders) Totipotent ability to give rise to all the cell types of the body plus all the cell types that make up the extra-embryonic tissues such as the placenta. Multipotent ability to give rise to a number of closely related family of cells. Oligopotent ability to give rise to only a few cells (i. e. lymphoid or myeloid stem cells) Unipotent ability to produce only one cell type; their own. Development: differentiate into all the cells of our body. Internal repair: regenerate organs (blood, skin, intestinal tissue, etc. ) Two types of stem cells based on their site of origination & degree of specialization. Embryonic stem cells (esc: most research on mouse & human embryonic stem cells, but in vitro mesc are not identical to hesc. Instead, they can make the circulatory system, nervous system, immune. Neurons: most adult stem cells are lineage restricted hesc research is ethnically very controversial.
