Biology 1202B Lecture 5: LECTURE 5
15 Oct 2018
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Enzymes do not alter the g of the reaction. Energy is transferred to the target molecule via transfer of pi. Metals are bound to the protein, necessary for protein function. Enzymes bring molecules together in proper orientation. Could interact with charges; what"s required to bring reaction into transition state. Enzymes may physically strain bonds = more likely to break. Continue adding increasing amounts of enzyme, reaction will occur in a linear fashion. Continue adding increasing amounts of substrate, will eventually reach a plateau (ln graph) Rate of conversion from products to reactants. Competitive inhibitors: substrate mimic; looks like substrate so that it can bind to active site of a protein. If competitive inhibitor is bound, it is impossible for actual substrate to bind and reaction to occur. Penicillin binds to transpeptidase and so it cannot synthesize peptide links. Noncompetitive inhibitors bind to allosteric site and alter enzyme conformation. Substrate can still bind to active site.
