Biology 1202B Lecture Notes - Lecture 13: Peripheral Chemoreceptors, Medulla Oblongata, Anaerobic Respiration
26 Feb 2019
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Mon, feb. 25/19 lecture 13: cellular respiration iii: understand cellular respiration under these circumstances, answers in ratios. From glycolysis, pyruvate is produced: pyruvate can undergo fermentation or pyruvate oxidation, nadh comes from the etc, nad+: nadh is low under hypoxic conditions, aerobic respiration is still occurring when the body is switched into anaerobic respiration. Hif-1 hypoxia inducible factor: activated under hypoxic conditions, hif1 beta is always in the nucleus, made in nucleus, hif1 alpha is in the cytoplasm. Inducible, in normoxic conditions, prolyl hydroxylases add a hydroxyl group to the kif1 alpha. It is sent to the proteasome for protein degradation: under normal conditions it goes to the proteasome, until oxygen levels are low, it will enter the nucleus and becomes the functional form of. Hif1: binds to hif1-beta and drives the transcription of various genes, anaerobic respiration, keeping the pyruvate in the cytoplasm, hif 1 stabilizers, many disease are occurring due to lack of oxygen to the various tissues.
