Biology 1202B Lecture Notes - Lecture 21: Pattern Recognition Receptor, Innate Immune System, Edward Jenner
30 Mar 2016
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Defence against disease began with smallpox: milkmaids were immune to smallpox when they previously had cowpox o. Cowpox was a less severe disease and much less likely to die: milkmaids were suscepible to cowpox because of job environments o o. Edward jenner caused litle boy to have cowpox and then infected the boy with smallpox who remained infecion free. Vaccinaion has eradicated smallpox technique of infecing with a similar but less severe form of pathogen. *once things have goten in, the irst things that happen and adapt immunity requires and organism to difereniate between self and foreign pathogen-associated molecular paterns (pamp) recognized by patern recogniion receptors (prr) Second line innate immunity and viruses o. Innate immunity is efecive at recognizing bacterial pamps: more diicult to recognize viral pamps locaion inside cell, size of virus (less physical surface area = less. Rna interference simulated by viral rna molecules to prevent translaion.
