Biology 1202B Lecture Notes - Lecture 23: 1000 Genomes Project, Single-Nucleotide Polymorphism, Human Genome Project
9 Apr 2016
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7 individual genomes sequenced in each (public and private) project. 12. generated a reference sequence: sequence which was most common at each nucleotide. 13. recognized that there were many nucleotides which were polymorphic: varied between individuals, single nucleotide polymorphism (snp) 14. took the most common nucleotide, in doing so they recognized huge amounts of variation between individuals. 16. project where they sequence over 1000 genomes from geographically distinct places around the world. Identify the geographic distribution of snps in the human population. 22. wanted to identify geographic distribution of common snps (whats common in diferent places) 23. more rare polymorphisms tend to cluster in geographic speciic areas- we can compare snps between people and identify genetic ancestry. 25. encode project attempts to describe all functional areas of the genome: deined function as a discrete genome segment that encodes a deined product ie: protein or non-coding rna. 26. not only the genes themselves, but also the regions which are involved in expressing genes- promotor, enhancer.
