Biology 1202B Lecture Notes - Lecture 18: International Hapmap Project, Non-Coding Rna, Copy-Number Variation
10 May 2016
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Document Summary
Approximate size of the genome (3 billion base pairs) known. The sequence of a number of genes and genomic regions known. Human genome project goal sequence and characterize the human genome. Human complexity is not due to having more genes. 3. 09 gb of dna 22,287 gene loci. Rather, it is due to regulation of those genes. Of the genes whose function is classified, what is the function of the largest category of human genes: membrane transport protein, structural proteins, chaperones, transcription factors. Hgp and celera sequenced a number of individuals. Thus the sequence of the published human genome is a consensus. Not the sequence of a single individual. While the majority is the same between individuals there are many individual differences. Some regions of the genome are difficult to sequence. Gaps in sequence (red) heterochromatic/ repetitive dna. Half of the human genome is repetitive dna. Once we had the reference it was time to look for variants snps.
