Biology 3316A/B Lecture Notes - Lecture 8: Cyclin D1, Colorectal Cancer, Vinculin
13 Jul 2019
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Why have it: born with more neurons. Lecture 8: seen in almost animals with some sort of apoptosis pathway. Role of ca2: worst case scenario = too much in the cytosol, apoptosis: Proteasome: rhomboid protein 1 promotes colorectal cancer growth. Just seems to be expressed in equal amounts in every single lane. Several western blots because there are multiple antibodies. Akt = would be equal across the board. This is a pro-survival pathway p-akt = levels would go up. It may not go on in all the tissues at the same time, which makes it difficult to see: the limited resolution. Apaf-1 binds to cytochrome c forms an apoptosome: that is the signal to activate caspase 9, which cleaves the pro-form of caspase 3 that sets in motion the degradation pathway. Is this the intrinsic of extrinsic pathway: this is going on within the cell, you triggered the cytochrome c from the mitochondria so it is happening from within.
