Biology 3597A/B Lecture Notes - Lecture 5: Stem-Loop, Dna Replication, Pyrophosphate
25 Jan 2017
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Once you get to 9-12 nucleotides you get elongation. Conformation change in rna polymerase makes it more processive. As soon as you have transcript bubble - when open complex is formed but only when you get to 9-12 elongation happens. Know relative locations of things and amount of dna covered (polymerase, tata etc) Pyrophosphate removed from nt two phosphates a(cid:374)d ha(cid:448)e (cid:271)o(cid:374)d for(cid:373)atio(cid:374) (cid:449)ith 3". After each nt laid down have one pair complementary down stream and one pair upstream will lose contact with complementary base. Dna replication plays role in way majority of genes are organized in bacteria. Dna pol moves in different directions from origin. Majority of genes in ecoli and bacteria are transcribed in same direction as replication. Rna and dna poly moving in same direction. Frequent replication of genome divide super fast but still have to operate and transcribe genes works out if most genes transcribed in same direction as dna pol replicates.
