Biology 3602A/B Lecture Notes - Lecture 9: Procollagen-Proline Dioxygenase, Hif1A, Tx Network
5 Aug 2016
School
Department
Course
Professor
Document Summary
Some animals have adapted to high altitudes; if we look at the o2 dissociation curve for hb from a couple of those animals in south america (vicuna (related to camels)+llama (camelids) and other lowland animals): P50 is a lot lower / line is shifted to the left in vicuna/llama. Thus low p50 means hb has higher affinity for o2 easier for hb to extract o2 at the lung. This is a change of amino acid sequences of hb itself that has happened over generations (hence adaptational) Consequence: easier for other mammals to offload o2 and not as easy to offload o2 for camelids (it"s a tradeoff) Evolutionarily, it was more worthwhile for camelids to have high affinity to o2. You can change the conditions in which rps are working to change the p50 of that rp without changing the aa sequence.
