Biology 3316A/B Lecture Notes - Lecture 1: Granulosa Cell, Interactome, Connexin
20 Jan 2018
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Imp to regulate heart rate, peristalsis: molecules entering oocyte, granulosa cells make movements, peristaltic wave that through muscles (due to contractions, provide for 2-way flow, mutations cause at least 8 known diseases. If it was a peptide how many can go through the gap junctions: each aa is about 110da so 11 can go through. 400 mutations in the cjb1 gene encoding connexin32* Luteinizing hormone, follicle stimulating hormone, growth hormone, thyroid stimulating hormone, parathyroid hormone, adrenaline *: growth hormone is 191 aa. Can it go through gap junctions: no bc it is too big. Paracrine signaling: stimulate one cell and u release the ligand, short range signaling. Autocrine signaling: target sites on the same cell, e. g. Wnt, vascular, endothelial growth factor, interleukins, eincosanoids: what are platelets, form clots. Signaling by plasma-membrane-attached proteins: juxtacrine (contact-dependant) signaling, eg. Hydrophobic signals readily cross plasma membrane require a cytosolic carrier protein.
