Chemistry 2223B Lecture Notes - Lecture 7: Postmarketing Surveillance, Food And Drug Administration, Tetrahydrofolic Acid
15 Mar 2015
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Development of new drugs classified into three stages: drug discovery & preclinical evaluation, clinical evaluations, fda approval, marketing and post-market surveillance. Identify new drug candidates that have the potential to achieve a desired biological effects these are called new molecular entities or new chemical entities. May require research on fundamentals of disease or biological processes, and on the action of existing drugs. Extraction from natural sources: ex. morphine, opiates, penicillin, method 2. Used to make better compounds form those indetified serendipitously or by purposeful searching activity: sars determine the effect of structural changes to the molecule on its. Ex. methylate top oh morphoen into codeine. Diacetylmorphine make it more addictive by masking polarity able to cross. In silico technique computers design a drug that binds to specified target. Ex. relenza & tamiflue inhibit influenza enzyme neuraminidase. Allows rapid, automated screening of huge libraries of compounds. Usually prepared by combinatorial synthesis (combichem) against a multitude of possible targets.
