Chemistry 3393A/B Lecture 13: Topic M: Quantitative Structure-Activity Relationships
8 Apr 2017
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This topic covers the following sections of the textbook: Chapter 18: 18. 1 18. 6, 18. 8, 18. 9 (read 18. 10 if interested) After studying this chapter, you should be able to do the following textbook questions: And these multiple-choice questions on the textbook"s website (http://global. oup. com/uk/orc/chemistry/patrick5e/): chapter 18: 1 5, 7 14. Refer to the craig plot and the topliss schemes (will be provided during the exam) Sar is the study of changing the structure of a drug to look at its functions. Quantitative sars identifies and quantifies the physiochemical properties and see if they are related to biological activity. The data are fit into mathematical equations which can be used to predict what happens when a different substituent is used. Relationship between biological activity (or binding) and log p. Biological activity is how active a drug is; how much of the drug you need.
