Microbiology and Immunology 2500A/B Lecture Notes - Lecture 8: Major Histocompatibility Complex, Memory T Cell, Cytotoxic T Cell

• School: Western University
• Department: Microbiology and Immunology
• Course: Microbiology and Immunology 2500A/B
• Professor: Kelly Summers

Document Summary

Role of mhc class i and ii molecules in antigen presentation and t-cell activation. Types of antigen-presenting cells and t-cells that respond to each. How dendritic cells initiate primary immune responses. Function of effector cytotoxic t-cells, th1 cells, th2 cells, tfh cells. T-cell receptors remain bound to the cell (it is not soluble, unlike b-cell receptors) All the daughter cells of naive th and. Ctl cells that arise from clonal expansion become effector cells. Some of them remain as memory t-cells after the infection is cleared. Recall: b-cell receptors can bind both protein and non-protein antigens. However, t-cell receptors (tcr) can only bind to. Tcr can only bind to protein antigens because it is hydrophilic. Can"t bind to hydrophobic lipids or polysaccharides. Tcr can"t directly bind to the antigenic epitope. An epitope is a peptide from a protein antigen. The antigenic epitope has to be on a major histocompatibility complex (mhc) molecule for the tcr to bind on.