Microbiology and Immunology 2500A/B Lecture Notes - Adaptive Immune System, Mannose, Innate Immune System

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Published on 19 Apr 2013
School
Western University
Department
Microbiology and Immunology
Course
Microbiology and Immunology 2500A/B
Professor
Jan 11 - Innate Immunity Part 1
- two main types of immune responses:
o innate
o adaptive
o also have passive not your own immune system, one that you
acquired from a donor (plasma bag) or from maternal antibodies
when you’re born
- two main defenses of immune system:
o cells
o soluble proteins
- innate immunity is the first line of defense against a pathogen
o activated immediately to destroy pathogen it is constantly ready
o effective at stopping majority of pathogens at early stage
- properties of innate immunity:
o inherited from parents you are born with it
everyone has the same innate defenses = well conserved in
evolution
o as vertebrates, we also have adaptive immunity
o always initiated when pathogen contacts body
o responds immediately to pathogen
o no memory
adaptive immunity remembers pathogen
innate doesn’t remember same immune response to
identical pathogen with each exposure = non-adaptive
- innate immune defenses
o barriers block pathogen entry into tissues (first line of defense)
modes of pathogen entry into the body:
RESPIRATORY TRACT (BREATHING) you inhale into
lungs
SKIN (WOUND) - injured skin ex, you cut yourself or
get a hangnail
GASTROINTESTINAL TRACT (INGESTION) - digestive
system GI tract ex, eat contaminated food (food
poisoning)
REPRODUCTIVE TRACT sexually transmitted
Main barrier that prevents pathogen entry = epithelial cells
(endothelial cells line blood vessels)
Salivary gland duct
Gal bladder simple columnar epithelial cells
Bladder hard for pathogen to break through
mechanical barriers expelling/flushing out pathogen
ex, coughing, sneezing, vomiting, diarrhea, tears (has
enzymes), saliva (has enzymes)
chemical barriers
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Document Summary

Properties of innate immunity: inherited from parents you are born with it. Everyone has the same innate defenses = well conserved in evolution: as vertebrates, we also have adaptive immunity, always initiated when pathogen contacts body, responds immediately to pathogen, no memory. Adaptive immunity remembers pathogen innate doesn"t remember same immune response to identical pathogen with each exposure = non-adaptive innate immune defenses: barriers block pathogen entry into tissues (first line of defense) Modes of pathogen entry into the body: Respiratory tract (breathing) you inhale into lungs. Skin (wound) - injured skin ex, you cut yourself or get a hangnail. Gastrointestinal tract (ingestion) - digestive system gi tract ex, eat contaminated food (food poisoning) Main barrier that prevents pathogen entry = epithelial cells (endothelial cells line blood vessels) Gal bladder simple columnar epithelial cells. Bladder hard for pathogen to break through. Ex, coughing, sneezing, vomiting, diarrhea, tears (has enzymes), saliva (has enzymes)

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