Microbiology and Immunology 2500A/B Lecture Notes - Lecture 3: Colony-Stimulating Factor, Pattern Recognition Receptor, Hematopoietic Stem Cell
4 Dec 2017
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Describe 3 ways tnf, il-1 and il-6 are important in innate immunity. Describe 2 ways type i ifn provides immunity against viral infections. Explain how c3a and c3b function as innate immune defenses. Type i ifn: complement protein 3 (c3) Small proteins secreted by activated nucleated cells. This is how cells communicate with other cells, and also to itself = messengers. Activates or suppresses most cell behaviors (i. e. proliferation, growth, maturation, survival) Have a role in both innate & adaptive immunity. Clinical note: cytokines in clinical use/trials tell cancer cells to cease proliferation. Cytokine binds to its receptor expressed on a cell surface, which then signals the cell how to behave. (no binding = no signaling: cytokine cytokine receptor signal to cell. Types of cytokines (key role in innate immunity) Note: hematopoiesis is regulated by cytokines via hematopoietic stem cell that is multipotent. An activated cell via inflammatory stimuli secretes many cytokines simultaneously.
