Microbiology and Immunology 2500A/B Lecture Notes - Lecture 4: Natural Killer Cell, Cytokine Receptor, Progenitor Cell
17 Jan 2018
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We do get intracellular bacteria but natural killer cells are not effective in eliminating intracellular bacteria (only viral) How does bacteria become intracellular: escapes death when enters phagocyte so resides living in phagocyte, requires t cell immunity to remove. Intracellular bacteria are bacteria that evade phagocytosis, so live/replicate inside a phagocyte: how, resistant to enzymes of lysosome, bacteria live in phagolysosome. Fusion inhibited between lysosome and phagosome, so acids and enzymes not released: bacteria live in phagosome, bacteria escapes phagosome and enters cytoplasm. Proteins: cytokines pro-inflammatory = tnf, il-1, il-6 chemokines type i ifn, complement protein 3 (c3) Cytokines are small proteins secreted by activated nucleated cells how cells communicate with other cells, and also to itself. = (cid:862)(cid:373)esse(cid:374)gers(cid:863) dictate really all the cell behavior cell must be activated, it then can secrete cytokines activate or suppress most cell behaviours -- proliferation, growth, (cid:373)aturatio(cid:374), survival Cytokines have a role in both innate & adaptive immunity.
