Microbiology and Immunology 2500A/B Lecture Notes - Lecture 5: Epitope, Plasma Cell, B Cell

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Section 5 : b cell immunity extracellular pathogens and inactivate soluble proteins (e. g. toxins) Bcr binds directly to protein and non - protein antigens expresses multiple copies of a bcr specific to one unique antigenic epitope. Expressed on naive and memory b cells surface of. B cell development lymphoid progenitor pro b cell pre b cell cell. Igm and 1yd bcrs ( identical co - express specificity through slt. Apoptosis after a few months variable region , different constant region) Occurs in slt or t on binds. Mhc class 11 presents exogenous peptides exogenous peptide in mhc class il binds to. Tfh cell also undergoes clonal expansion t. si:1#. Need naive t cell to differentiate into effector tfh cell. Same peptide presented in mhc on dc as on naive b cell class 11. F) slt and circulate for years secrete igm abs (not. Somatic hypermutation (in dark zone) : changes variable region rearrangements gene occur.

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