Microbiology and Immunology 2500A/B Lecture Notes - Lecture 12: Ixodes Scapularis, Lyme Disease, Rheumatoid Arthritis
18 Mar 2020
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Untreated can lead to arthritis, carditis and nervous system manifestations. A "spirochete" (spiral bacteria) was isolated from ticks, then from skin, blood. Hard bodied ticks: burgdorferi mostly transmitted in na through ixodes scapularis and ixode. Not born with b. burgdorferi, must acquire the pathogen. Sit on grass/shrubs and wait for host to pass by. Secretes a local anesthetic so may not even feel the bite. Transmission does not occur within first 24 hours. Ticks suck blood slowly for several days and appear grey when engorged od and csf of pts des pacifica. Lyme disease: burgdorferi: gram -, spirochete, no lps, extracellular. Ticks suck blood slowly for several days and appear grey when engorged. Gram - spirochete, thin and long (no lps, despite gram -) Transmitted to different mammalian hosts through tick bites. Hematogenous dissemination is a central event in the development of the. Contain periplasmic (between pm and outer membrane) flagella. Wrap around cells to produce a corkscrew shape.
