Microbiology and Immunology 2500A/B Lecture Notes - Lecture 9: Granuloma, Lepromatous Leprosy, Coagulase
6 Dec 2015
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Intracellular pathogen obligate human pathogen (lives within macrophage s) Mycolic acid in cell envelope: bovis, avium. 4-6 week s to get small colon ies. Plague of justinian (first pandemic 541 ad . European pop reduced global pop from 450 to. Mid-19 century - >12 million deaths in china and. Stage 2: begins 7-21 days after initial exposure. T cell activated macrophages can kill tb, macrophages at the center remain harder to be activated; Stage 4: erosion of granuloma route of transmission -> active tuberculosis (lower immunity) Chine in 1850s and spread to all cont. 2-4 days (v) fleas bacteria live in rodents (starving fleas. Painful swellings (buboes) of lymph nodes in the armpits, legs, neck or groin. High fever, delirium and mental deterioration, large blackish pustules that burst, vomiting of blood, bleeding in the lungs. Only 10% of tb infected people develop active disease. Fever, chills, night sweats, fatigue and weakness, chest pain and shortness of breath.
