Microbiology and Immunology 3300B Lecture Notes - Lecture 1: Red Blood Cell, Microscope Slide, Cell Culture
9 Dec 2016
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Antibody for undesired cell types (leukemia cells), or molecular catalyst for a desired enzymatic reaction. Antibodies have hypervariable region capable of interacting with antigens of any kind with high specificity and variability. Could be useful for neutralizing antibodies to toxins (snake venom), to pathogens. Originally achieved by kohler and milstein in 1975. If individuals b-cells make one antibody with one specificity, all we need is a technique to clone that and it should be able to make unlimited quantities of this. Monoclonal antibodies generating large quantities of antibody molecules with a (hiv, ebola), to cytokine (tnf in rheumatoid arthritis), or a complement-fixing. Monoclonal antibodies have been used for all of these purposes relatively easy. Identification of which cell type makes antibodies was known that antibodies proof that a specialized subset of lymphocytes was: bcells are the precursors of plasma cells secrete large antibodies in.
