Microbiology and Immunology 3300B Lecture Notes - Lecture 12: Clonal Deletion, Immunoglobulin Light Chain, Immunoglobulin Heavy Chain
9 Dec 2016
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Document Summary
B-cell receptors and antibodies consist of four polypeptide chains linked by disulphide bonds. Comprised of two heavy chain and two light chain proteins. Both light and heavy chains are made of ig protein domains founding members of these domains heavy chains have 5, light chains have 2 chain more specifically, requires the variable region from both of them. Same thing for the heavy chain variable has. Within one person, the amino acid sequence of the constant region is the same but the amino acid sequence of the variable region will differ even in a single person. Antigen binding domain has a variable domain of one heavy chain and one light different within one person, and the constant will be the same. The domains of immunoglobulin molecules are structurally similar. Light chain has two ig domains; constant region has 7 antiparallel beta strands and the variable has a total of 9 antiparallel beta strands.
