Microbiology and Immunology 3300B Lecture Notes - Lecture 24: Granulocyte Macrophage Colony-Stimulating Factor, Cell Adhesion Molecule, Selectin

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Learning objectives understand the phases of an immune response: initiation of different types of immune responses, resolution immune memory, the secondary response, t cell and b cell contributions. Adaptive immune system the adaptive immune system is triggered after a certain threshold of infection: this takes several days. Must find a way to drop down immune response after because it is metabolically expensive, but not to a level that leaves you unprotected. Pathway of na ve t cell once activated by a dc, becomes a th0 activated but not committed. Induced by ifn gamma: sourec from nk, nkt, cd8 t cells. Expanded by il12 important for proliferation: source: dcs and macrophages, tlr activation. Effector mechanisms: activation of cd8 t cells, activation of phagocyte killing mechanisms, class switch to igg2a, igg3. Induced by il4: source: inkt, mast cells, basophils and th2 t cells. Effector mechanisms: drive class switch to ige, igg1. Treg inhibitory: will inhibit th1, th2 and th17.

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