Microbiology and Immunology 3300B Lecture Notes - Lecture 16: Immune System, Immunoglobulin D, Mitosis
20 May 2016
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Document Summary
Have properties of being long lived and replenishing cells for your whole life time. Blood cells come from the hematopoietic stem cell lineage from the bone marrow. Hematopoietic stem cells can branch into the myeloid and lymphoid branches. Growth factor receptors involved in blood cell development. Stem cell antigen marker (sca) shuts off as development occurs: it is downregulated upon differentiation in lymphoid lineages. Ckit, fit and il7r are receptors for growth factors to stimulate development of growth factors: these transduce factors for survival, cell division and survival. Rag genes are translated only as the b cell develops. In mammals, development of lymphocytes occurs in the bone marrow (in adults) During embryogenesis, lymphocyte development occurs in the spleen. Blood cell development occurs from hsc which are in close contact to supporting cells like stromal cells and osteoblasts: as they mature, they get closer to the arteries.
