Microbiology and Immunology 3300B Lecture Notes - Lecture 1: Sirp, Complement System, Cd31
20 May 2016
School
Department
Professor
Document Summary
And cellular responses such as b cells and t cells. How do pathogens create damage: direct mechanisms of tissue damage, exotoxin production a. i. Toxins produced specifically to damage the host: endotoxin b. i. metabolites that cause inadvertent damage not produced to damage the host, direct cytopathic effect c. i. Indirect mechanisms of tissue damage by pathogens a. Large soluble antigens are bound to multiple sites by antibodies. Antigens cross link and can lodge in highly vascular places: anti-host antibody b. i. Pathogens trick host into attacking itself: cell mediated immunity c. i. When t cell comes in and kills pathogen infected cell kills own cell in the process. Innate a: non-antigen recognition of pathogens and passive mechanisms such as barriers. Independent from recognizing an antigen: adaptive a. Innate and adaptive immunity does not exist in the real world. Pamp: pathogen associated molecular pattern: pamps are evolutionary conserved because it is vital to the pathogenesis of the pathogen.
