Microbiology and Immunology 3820A Lecture Notes - Lecture 14: Immunosuppression, Cell-Mediated Immunity, Gram-Positive Bacteria
9 Dec 2016
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Slow growth, poor staining and acid fastness (i. e. once stained, resistant to decolourization by acid) Cell walls that are 60% lipid, including unique long chain fatty acids called mycolic acids. Wa(cid:454)(cid:455) greas(cid:455) ki(cid:374)d of (cid:272)ell e(cid:374)(cid:448)elop a(cid:374)d (cid:449)all stru(cid:272)ture that does(cid:374)"t stai(cid:374) (cid:448)er(cid:455) (cid:449)ell (cid:271)ut o(cid:374)(cid:272)e. Intracellular it does it holds stain very well. Once stained with acid fast stain, kinion stain, once stained they are resistance to the colorization of alcohol and alcohol with acid, cant bleach them at all. Once infected you will probs never get rid of them. Mycobacteria classification: tubercle bacilli complex, mott (mycobacteria other than tubercle bacilli, mycobacteriam leprae (causal agent of leprosy, tuberculosis complex. Much greater problem 100 years ago then it is now, bovis refers to bovine which is. Includes tb sensostricto and the other four: these all cause tb cattle: 1/3 of the worlds population is infected, ~30 million active cases. If the sputum stains negative for afb patient is non-infectious.
