Microbiology and Immunology 3820A Lecture Notes - Lecture 2: Mutation Rate, Sepsis, Monocyte
4 Mar 2016
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O the majority (most) pathogens enter through the mouth. 10x bacteria in the body then cells and 10% of body weight. Mucus; secreted by goblet cells. Goblet cells are interspersed in epithelial cells and produce mucus. Shows many barriers beyond just epithelial cells, many barriers for bacteria to enter. Benfit us: nutritional and digestive benefit, provide immune protection (barrier) Harmless to us, but . : many normal flora are opportunistic pathogens can become pathogenic when opportunity arises. = both pathogenic bacteria and beneficial bacterial flora serious problem when cells begin to leak etc look at graphic. Lecture 2 - innate immunity. 1st line of defense against a pathogen. It is constantly ready to destroy a pathogen: effective stopping majority at early stage. Properties: barriers block pathogen entry into tissues. Innate cells rapidly eliminate pathogens that enter tissues. If innate immunity is not successful certain innate cells initiate adaptive immunity to help eliminate the pathogen.
