Microbiology and Immunology 3820A Lecture 15: (Dr. Colby) Lecture 9 - The Rickettsiae
4 Mar 2016
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Characteristics (dr. colby) lecture 9 - the rickettsiae. Charles i abandoned plans to march on london in 1643 because of an outbreak of epidemic typhus. 1741: prague fell to french army after 60,000 defenders died of typhus. Epidemic in ireland 1816- 1819: 10% of population diseased: was typhus, not starvation killing them. Like chlamydia, the rickettsiae are obligate intracellular parasites: originally thought to be viruses. Small, gram negative short rods. Gram stain poorly: intracellular location makes giemsa the best choice: don"t penetrate host cells very well. Rickettsiae are capable of making their own atp but prefer to act as energy parasites lazy! Enter cells by stimulating phagocytosis. This is how they gain entry. Ehrlichia paul erling, hero of microbiology: neorickettsia. Coxiella: divided into the spotted fever group and the typhus group. Transmitted by lice, ticks, fleas or mites. All invade the capillaries at site of entry and attach to vascular endothelial cells produce bv problems.
