Microbiology and Immunology 3820A Lecture Notes - Lecture 12: Necrosis, Sepsis, Enterotoxin
4 Mar 2016
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Functional definition of an anaerobe: (dr. colby) lecture 6 - anaerobes. Strict anaerobes lack superoxide dismutase, which in aerobic organisms serves to protect against superoxide (o2- ) Obligate anerobe sits at the top to use oxygen. Strict anerobes go far down the test tube to the bottom. Facultatative anerobes can grow with or without, prefer oxygen, grow more quickly with oxygen, but also without. Aerotolerant don"t care about oxygen. Anaerobes: widely distributed in soil, fresh and salt water, the gi tract, genitourinary orifices and on the skin. A small number of anaerobes are commonly associated with disease, mostly endogenous. Infections caused by endogenous anaerobes are associated with surgery, radiotherapy, malignancy or prior antibiotic therapy, particularly with aminoglycosides (active against aerobes) Clinical clues to anaerobic infection. Foul odour to lesion or discharge use fermentation instead of oxygen (away from oxygen), smells bad, gas. Infection located in proximity to mucosal surface. Bite wounds deep wounds from punch to teeth, need specific antibiotics.
