Microbiology and Immunology 4100A Lecture Notes - Lecture 6: Lactoferrin, Ferritin, Myoglobin
22 Dec 2019
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Elementsin groups 3 12 ofperiodictablewithan incompleteelectronshell enablestheexistence ofmultiplevalences. O si at fe ca mg nas k. Oh fe toh cfentonreaction: fe t hao. Wecan"tget rid of iron theamountthat wetakein wekeepfor life. Nutritional andinhalation u n lonai nd i kaako. Eg bantusiderosis foundin africa is causedbyhighironcontent in locally brewed beer. Ypestis y enterocolitica pasteurellamultocida p haemolytica klebsiella pneumoniae. Corynebacteriumrenateclostridiumperfringens aeromonas hydrophila pseudomonas aeruginosa e coli l monocytogenes vibriocholerae neisseriameningitidis. Transferrin bindingprotein tbp will bringtransferrin and removetheironto passintothecellsincetransferrin istoolarge. Expresscellsurfaceproteinthatbindshemoglobinandcanstriptheheme off of host pre hot hemoglobinandtransferthehemethroughthepeptidoglycanlayertoenterthecelltobe brokendowntogettheiron lsdsystem p l he e o hmoglobi ca. Catecholate acarboxylate cellswillcontainareductaseinsidethat wi l reduceferricironintoferrousiron causingittobe releasedfromthesiderophorewhichwillberecycled. Siderophorebindsto totbdtcton bdependenttransporter causeston b independent liganddependentconformationalchangeinthereceptorprotein uponligandbinding. Receptor proteinreturnstooriginalconformationupontransportofiron siderophorecomplex outermembranereceptoris a beta barrelwherethen terminusfunctionsas a cork siderophores orange yellow coma. Conformational change leadsto exposure of tomb box red and subsequentinteractionwithtomb. Ecolihasmanyreceptorproteinsforsiderophoresthataremadeby fungi as wellasreceptorsforsiderophores itmakesitself one mustconsider why doweneed a receptorproteinsiderophores. Cowis uptake foriron that and is indicating aerobactin essential virulence.
