Medical Sciences 3999A/B/Y Lecture Notes - Lecture 4: Epidermolysis Bullosa Simplex, Epidermolytic Hyperkeratosis, Desmoglein-1
2 Feb 2020
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Document Summary
Involved in movement, structural support, shape-change, construction, changes in cytoplasmic consistency, etc. Made up of and tubulin (polarized) Microtubule associated proteins (maps): polymerizes and stabilizes the structure. Mutations can cause microtubule collapsing --> tangled amyloid fibres. Degenerative diseases like alzheimer"s (mutation in tau, related to maps) Treatment: ache inhibitors (slows degradation of synaptic ach), Galantamine (augments nicotinic receptors for ach), rivastigmine (ache inhibitor and for dementia) Intracellular vesicular transport by kinesin (anterograde) and dynein (retrograde) Makes up components of centrioles, basal bodies, cilia and flagella. Drugs affecting polymerization of microtubules can be used for cancer therapy (inhibits mitotic cell division by preventing spindle formation) Provides mechanical support to cells; not polarized (no + and - end) Keratins: ~20 proteins in the epithelia for different types (i. e. hair, nail, feathers, etc. Provides defense against abrasions and loss of water and heat. Desmin (skeletin): found in smooth muscle and in the z-disks (skeletal and cardiac)
