Pharmacology 2060A/B Lecture Notes - Lecture 8: Intrinsic Activity, Partial Agonist, Receptor Antagonist
9 Dec 2016
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Document Summary
In the last module we learned that most drugs work by binding to receptors. There are two receptor theories that we use to describe drug receptor interactions: the simple occupancy theory. The intensity of a drug"s response is proportional to the number of receptors: the maximal response occurs when all the receptors are occupied. occupied. This implies that two drugs that act at the same receptor should produce the same effect. We know this because there are many drugs that act at the same receptor yet have different efficacies: the modified occupancy theory. The modified occupancy theory identifies that some characteristics of drug receptor. In summary, in addition to accounting for the number of receptors occupied, the modified occupancy theory takes into account the affinity of the drug for the receptor and the ability of the drug to activate the receptor. Affinity is the attraction that a drug has for its receptor.
