Pharmacology 2060A/B Lecture Notes - Lecture 10: Thiopurine Methyltransferase, Histamine Receptor, Drug Allergy
9 Dec 2016
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Document Summary
Module 10 adverse drug reactions and medication errors. Adverse drug reactions (adrs) are the unintended and undesired responses from. Adverse drug reactions are an enormous societal health problem. Canadian research suggests that 7. 5% of hospital admissions in canada are attributed to adverse drug reactions. Adverse drug reactions can include: side effects. Secondary to the main therapeutic effect of the drug and are expected. Occur at normal therapeutic doses and are often unavoidable. Often due to poor specificity or selectivity of the drug and receptor that it binds to. Example: antihistamines act by blocking h1 histamine receptors to prevent the symptoms of allergy (i. e. runny nose, watery eyes): side effects include drowsiness, dry mouth and urinary retention. In the figure you can see that histamine binding to the histamine receptor in sinuses causes vasodilation which results in runny nose and watery eyes.
