Pharmacology 2060A/B Lecture Notes - Lecture 3: Body Water, Adipose Tissue, Blood Proteins
14 Jan 2017
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Document Summary
Drugs distribute into compartments in the body where they may be stored, metabolized, excreted or exert their pharmacological effect extracellular fluid that surrounds cells. Low molecular weight, water- soluble drugs distribute in the interstitial space. The body"s compartments include: interstitial space the, total body water includes, plasma the non-cell containing component of blood. Drugs: adipose tissue the body"s fat. Bone can be a reservoir for the slow release of some drugs: other tissues. Drug distribution is determined by: blood flow to tissues, ability of drug to move out of capillaries, ability of drug to move into cells. The more drug that distributes out of the blood, the lower the concentration of drug in the blood. Blood flow to tissues is a key determinant of drug distribution. In well perfused tissues such as the liver, kidney and brain, drug distribution is rapid. Distribution to tissues with lower blood flow such as skin, fat, and bone is much slower.
