Pharmacology 2060A/B Lecture Notes - Lecture 4: Critical Role, Caffeine, Analgesic

• School: Western University
• Department: Pharmacology
• Course: Pharmacology 2060A/B
• Professor: Andrea Di Sebastiano

Document Summary

4. 1 drug metabolism (cid:120) metabolism is the enzyme mediated alteration of a drug"s structure. (cid:120) metabolism is also referred to as biotransformation. (cid:120) sites of drug metabolism include: Everyone thinks kidneys are excretion but also play role in metabolism. Similarly, essential endogenous molecules synthesized by drug metabolizing enzymes are shown. (cid:120) note that even things like vegetables considered to be healthy would by toxic if we did(cid:374)"t have e(cid:374)zy(cid:373)es to process them! Therapeutic consequences of drug metabolism (cid:120) drug metabolism can have several different consequences. (cid:120) therapeutic consequences of drug metabolism are summarized below: increase water solubility of drugs to promote their excretion. Active (cid:198) more active ex morphine: activate prodrugs (prodrugs are inactive until metabolized) Prodrug (inactive) (cid:198) active drug: increase drug toxicity. First order (cid:120) in most clinical situations the concentration of lower than the metabolic is much drug capacity of the body.