Pharmacology 2060A/B Lecture Notes - Lecture 9: Analgesic, Qt Interval, Median Toxic Dose
4 Jan 2021
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Document Summary
In an ideal world the response to medications would be the same for every patient. Unfortunately in reality, response to medications is quite variable between patients. Because response to medications is variable, every patient"s response must be evaluated to ensure an adequate therapeutic response. The response to medication is influenced by: metabolism. Genetics gender, race, polymorphism, altered drug transporters, altered drug targets, altered drug. Environment exercise, circadian rhythm, occupation, smoking, alcohol, diet. Clinical trials are an important first step in determining interpatient variability to drug response. Phase ii clinical trials establish dose response information over a range of doses. To determine interpatient variability in response to medications, we first set an end point. I. e. if we were talking about an analgesic drug, the end point would be pain relief. From phase ii clinical trial data we can evaluate the number of patients that experience pain relief from each dose of the drug.
