Pharmacology 2060A/B Lecture Notes - Lecture 5: Distal Convoluted Tubule, Nephron, Lipophilicity
Document Summary
Drugs enter via renal artery hydrostatic pressure forces drugs into renal tubules (20% of total renal plasma flow) (ph + lipid solubility doesn"t affect filtration) Not filtered drugs leave glom via efferent arteriole and form capillaries that surround proximal tubule drugs secreted form blood surrounding tubules into lumen of proximal tubule. Concentration increases as drugs move to distal tubule (due to loop of henle which concentrates solutes) once in the distal tubule drug conc often exceeds conc in blood that surrounds tubule. Drugs and drug conjugates excreted in the bile enter the intestinal lumen. Intestinal bacteria can cleave conjugate metabolites leaving the original drug. The original drug may be reabsorbed in the intestine to re-enter the body. This process is known as enterohepatic recycling.