Pharmacology 2060A/B Lecture Notes - Lecture 9: Liver Disease, Kidney Disease, Rosuvastatin
11 Apr 2016
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Document Summary
In an ideal world, the response to medications would be the same for every patient. Unfortunately in reality, responses to medications is quite variable between patients. Because response to medication is variable, every patient"s response must be evaluated to ensure an adequate therapeutic response. The response to medication is influenced by genetics, disease state, and the enviro. Clinical trials are an important first step in determining interpatient variability to drug response. Phase 2 clinical trials establish dose response info over a range of doses. To determine interpatient variability in response to medications, we first set an endpoint. Is we were talking about an analgesic drug, the endpoint would be pain relief. From phase 2 clinical trial data we can eval the number of patients that experience pain relief from each dose of the drug. This data is plotted on a frequency distribution curve. The average effective dose (ed50) is at the peak of the frequency distribution curve.
