Pharmacology 2060A/B Lecture Notes - Lecture 5: Renal Artery, Efferent Arteriole, Proximal Tubule
26 May 2016
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Document Summary
Drug excretion- the removal of parent drug and drug metabolites from the body. Sites of drug excretion: kidney, bile, lung, breast milk. Renal drug excretion: kidneys account for majority of drug excretion, healthy kidneys limit duration and intensity of drug effects, decreased function prolongs the duration of action and intensity of drug effects. The nephron: basic structural/functional unit of the kidney, regulates water, electrolyte and drug excretion, controls blood volume, blood pressure, blood ph, and solute (including drug) excretion. Tubular secretion: un ltered glomerulus drugs leave by the efferent arteriole, which divide to form capillaries surrounding proximal tubule. The effect of age on renal function: kidney function is low in newborns. 40ml/min/1,73m^2: by 2, gfr reaches healthy adult gfr, as age increases, renal function decreases, and so renal drug excretion decreases. Some drugs eliminated into bile and excreted in feces.
