Pharmacology 2060A/B Lecture Notes - Lecture 3: Body Water, Plasma Protein Binding, Blood Proteins
26 May 2016
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The body"s compartments where drugs may be store, metabolized, excreted, or exert their pharmacological effect include: Where low molecular weight, water soluble drugs distribute: total body water- includes the uid in the interstitial space, intracellular. Uid, and the plasma: plasma- non-cell blood component. Where drugs strongly bound to plasma protein and high molecular weight drugs distribute: adipose tissue- fat. Where lipophilic drugs distribute: muscle- some drugs tightly bind to muscle tissue, bone- some drugs absorb onto the crystal surface of bone with eventual incorporation into the crystal lattice. Bone can be a reservoir for the slow release of some drugs: other tissues. The more drug that distributes out of the blood, the lower the [ ] of the drug in blood. Neonates have limited blood ow, thus limited distribution. Patients with heart failure of shock may have reduced blood ow. Solid tumours have low regional blood ow.
