Pharmacology 2060A/B Lecture Notes - Lecture 2: Gastrointestinal Tract, Bioavailability, Intravenous Therapy
26 May 2016
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Document Summary
Pharmacokinetics- the study of drug movement in the body, and what the body does to the drug. Composed of 4 basic processes: absorption, distribution, metabolism, and excretion. Absorption- the movement of the drug from the site of administration into the blood. The rate of absorption determines how quickly the drug effect will occur. The amount of absorption determines the intensity of the drug effects. Enteral routes of administration- involve gastrointestinal tract. Parenteral routes of administration- do not involve the gastrointestinal tract and involve injections: oral (enteral), intestine vs. stomach. Even though there is more surface area in the intestine, based on the ph effects, weakly acidic drugs should be better absorbed in the acidic environment of the stomach because the drugs would unionized. But the surface area of the stomach is small and covered in a thick layer of mucous. Therefore, the rate of drug absorption in the intestine will be.
