Psychology 2020A/B Lecture Notes - Lecture 2: Axon Terminal, Antibiotics, Neurotransmitter

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Drug dosages are usually expressed as milligrams or if given on a weight basis, mg/kg. A more potent drug has a curve to the left of a less potent drug. There is more than one dose-response curve for each drug there are different measures one could test: for an effect, not necessarily the drug. The higher the ratio the greater the difference between ld50 and ed50, and the less likely the chance that lethal or other toxic effects will occur. The margin of safety ratio is ld1/ed99. Phenomena associated with chronic drug administration can be depicted on the dose- response curve when a drug is taken chronically three things can occur. Tolerance progressive reduction of a drug effect for a given dose i. a right shift on the dsc administration. Sensitization drug effects that are progressively increasing over the course of repeated. a left shift on the dsc i. for example, cocaine.

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